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KMID : 0359920080270050569
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Korean Journal of Nephrology
2008 Volume.27 No. 5 p.569 ~ p.575
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Changes in Skin Color in Hemodialysis Patients According to Dialysis Modality
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Kim Chan-Ho
Park Sun-Young
Yoo Tae-Hyun
Han Dae-Suk
Kang Shin-Wook
Moon Sung-Jin
Kim Dong-Kie
Kim Dong-Hyun
Kim Hyun-Wook
Chang Jae-Hyun
Park Jung-Tak
Ko Kwang-Il
Kim Eun-Young
Chang Tae-Ik
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Abstract
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Purpose:Skin hyperpigmentation in end stage renal disease patients is known to be attributed to the accumulation of middle molecular weight (MMW) substances such as urochromic pigments and carotenoids. Therefore, there is a possibility that hyperpigmentation may be improved by high-flux hemodialysis (HF-HD) and online hemodiafiltration (HDF). This prospective study was undertaken to investigate the quantitative changes in skin color in HD patients according to dialysis modality.
Methods: Eighty-two stable ESRD patients undergoing HD were enrolled and divided into three groups according to their dialysis modality. Melanin index and erythema index of forearm and abdomen (nonsun exposed area), and forehead (sun exposed area) were measured by narrow-band reflectance spectrophotometer at baseline and after 12 months.
Results: There were no significant differences in the baseline values of melanin and erythema indices among the three groups. But the changes in forehead melanin index were significantly lower in HDF patients (-1.0+/-2.4%) compared to the LF-HD group (0.3+/-1.6%) (p<0.05), and forehead erythema index was significantly decreased in patients treated by HDF (-1.6+/-2.5%) relative to the lowflux hemodialysis group (-0.1+/-2.5%) (p<0.05).
Conclusion:The changes in skin color of sun exposed area were reduced by HDF, suggesting that enhanced removal of MMW substances by convective therapy may be of advantage to skin hyperpigmentation in ESRD patients.
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KEYWORD
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Dialysis, Hyperpigmentation, Hemodiafiltration
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